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KMID : 0545120090190091051
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 9 p.1051 ~ p.1054
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Distribution of Human Papillomavirus Type 58 Variants in Progression of Cervical Dysplasia in Korean Women
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Bae Jeong-Hoon
Cheung Jo L.K.
Lee Sung-Jong
Luk Alfred C.S.
Tong Seo-Yun
Chan Paul K.S.
Park Jong-Sup
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Abstract
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This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.
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KEYWORD
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Human papillomavirus (HPV), cervical intraepithelial neoplasia (CIN), HPV variants
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